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Literature summary for 1.3.1.22 extracted from

  • Bertics, P.J.; Edman, C.F.; Karavolas, H.J.
    Potent inhibition of the hypothalamic progesterone 5alpha-reductase by a 5alpha-dihydroprogesterone analog (1984), J. Biol. Chem., 259, 107-111.
    View publication on PubMed
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
4-Aza-4-methyl-5alpha-pregnane-3,20-dione competitive against progesterone, reversible, transition state analog Rattus norvegicus
NADP+ product inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00013
-
 progesterone
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female rat
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000062
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus progesterone Rattus norvegicus
0.0000118
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus NADPH Rattus norvegicus