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Literature summary for 1.3.1.22 extracted from
- Changes in pituitary, hypothalamic and brain progestin-metabolizing enzyme activities during lactation (1993), J. Steroid Biochem. Mol. Biol., 44, 299-303.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Rattus norvegicus | - |
- |
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + NADPH + H+ | Rattus norvegicus | activity is higher in hypothalamus of non-lactating female rats than in lactating | 5alpha-pregnan-3-20-dione + NADP+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
female rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| hypophysis | anterior | Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
r | |
| progesterone + NADPH + H+ | activity is higher in hypothalamus of non-lactating female rats than in lactating | Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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