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Literature summary for 1.3.1.21 extracted from

  • Najle, S.R.; Nusblat, A.D.; Nudel, C.B.; Uttaro, A.D.
    The sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske oxygenase, which is highly conserved in animals (2013), Mol. Biol. Evol., 30, 1630-1643.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Tetrahymena thermophila 16020
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Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila I7ML19
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADP+
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Tetrahymena thermophila cholesta-5,7-dien-3-beta-ol + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
Des7
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Tetrahymena thermophila

General Information

General Information Comment Organism
physiological function a knock out strain shows no differences in growth rates nor cell shape, neither in the presence nor in the absence of added sterols.Sterols found in wild-type are 83.44% cholesta-5,7,22-trien-3beta-ol as the major derivative, besides cholesterol itself, 0.55% cholesta-5,7-dien-3beta-ol and 3.84% cholesta-5,22-dien-3beta-ol. In contrast, in the KODES7 cell line, the only conversion product recovered is 92.76% 22-dehydrocholesterol Tetrahymena thermophila