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Literature summary for 1.3.1.21 extracted from

  • Koide, T.; Hayata, T.; Cho, K.W.Y.
    Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase (2006), Development, 133, 2395-2405.
    View publication on PubMed

Application

Application Comment Organism
medicine Smith-Lemli-Opitz syndrome is caused not only by disruption of the enzymatic role of 7-dehydrocholesterol reductase as a reductase in cholesterol biosynthesis, but may also involve defects in enzyme resulting in derepression of Sonic Hedgehog signaling Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Xenopus laevis
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Source Tissue

Source Tissue Comment Organism Textmining
embryo coexpression of enzyme and Sonic Hedgehog, Shh, during midline development in embryo. Enzyme functions as an negative regulator in Hedghog signaling at the level or downstream of Smoothend and affects intracellular Hedgehog signaling Xenopus laevis
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