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Literature summary for 1.3.1.21 extracted from

  • Honda, A.; Salen, G.; Nguyen, L.B.; Tint, G.S.; Batta, A.K.; Shefer, S.
    Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol DELTA7-reductase in liver and mononuclear leukocytes (1998), J. Lipid Res., 39, 44-50.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information feed-back inhibition through 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Homo sapiens cholesterol biosynthesis cholesterol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
monocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000605
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH cholesterol biosynthesis Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Homo sapiens cholesterol + NADP+
-
?

Synonyms

Synonyms Comment Organism
7-dehydrocholesterol DELTA7-reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens