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Literature summary for 1.3.1.21 extracted from

  • Niemiro, R.; Fumagalli, R.
    Studies on the inhibitory mechanism of some hypocholesterolemic agents on 7-dehydrocholesterol DELTA-7-bond reductase activity (1965), Biochim. Biophys. Acta, 98, 624-631.
    View publication on PubMed
Search for more literature for 1.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
1-[p-(beta-Diethylaminoethoxy) phenyl]1-(p-tolyl)-2-(p-chlorophenyl)ethanol i.e. MER-29 or triparanol Rattus norvegicus
20,25-Diazacholesterol
-
 Rattus norvegicus
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride i.e. AY-9944, hypercholesterolaemic drug Rattus norvegicus
Triparanol
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14
-
 7-dehydrocholesterol
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus
-
 cholesterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH
-
 Rattus norvegicus cholesterol + NADP+
-
 ?
cholesta-5,7-dien-3beta-ol + NADPH
-
 Rattus norvegicus cholesterol + NADP+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016 0.00024 trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
-
 Rattus norvegicus
0.0014
-
 20,25-Diazacholesterol
-
 Rattus norvegicus
0.047 0.083 Triparanol
-
 Rattus norvegicus