Literature summary for 1.21.3.1 extracted from

Douma, R.D.; Verheijen, P.J.; de Laat, W.T.; Heijnen, J.J.; van Gulik, W.M.
Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum (2010), Biotechnol. Bioeng., 106, 608-618.

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Organism

Organism	UniProt	Comment	Textmining
Penicillium chrysogenum	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O	isopenicillin-N synthase is the main rate-limiting enzyme for penicillin-G biosynthesis	Penicillium chrysogenum	a

Synonyms

Synonyms	Comment	Organism
IPNS	-	Penicillium chrysogenum
isopenicillin-N synthase	-	Penicillium chrysogenum

Expression

Organism	Comment	Expression
Penicillium chrysogenum	a developed gene regulation model predicts the expression of this rate limiting enzyme based on glucose repression, fast decay of the mRNA encoding for the enzyme as well as the decay of the enzyme itself	additional information

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Release 2023.1 (January 2023)