Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.3.1 extracted from

  • Brown-Marshall, C.D.; Diebold, A.R.; Solomon, E.I.
    Reaction coordinate of isopenicillin N synthase: oxidase versus oxygenase activity (2010), Biochemistry, 49, 1176-1182.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Reaction

Reaction Comment Organism Reaction ID
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O the hydroperoxide-ferrous intermediate, formed by O2-activated H atom abstraction from the substrate, can exploit different reaction pathways and interactions with the substrate govern the final pathway Aspergillus nidulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-hydroxyisovaleryl ester + O2 for this substrate analogue (ACOV) lacking an amide nitrogen IPNS exhibits oxygenase activity Aspergillus nidulans ?
-
?
delta-L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2 for the native substrate IPNS shows oxidase activity Aspergillus nidulans isopenicillin N + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
IPNS
-
Aspergillus nidulans
isopenicillin N synthase
-
Aspergillus nidulans