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Literature summary for 1.20.4.2 extracted from
- Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase (1999), Chem. Res. Toxicol., 12, 1278-1283.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | stimulates | Oryctolagus cuniculus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.1 | - |
monomethylarsonate | - |
Oryctolagus cuniculus | |
| 20.9 | - |
dimethylarsonate | - |
Oryctolagus cuniculus | |
| 109 | - |
arsenate | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylarsonate + glutathione | Oryctolagus cuniculus | rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver | methylarsonite + oxidized glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arsenate + glutathione | - |
Oryctolagus cuniculus | arsenite + reduced glutathione | - |
? | |
| dimethylarsonate + glutathione | - |
Oryctolagus cuniculus | dimethylarsonous acid | - |
? | |
| methylarsonate + glutathione | rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver | Oryctolagus cuniculus | methylarsonite + oxidized glutathione | - |
? | |
| monomethylarsonate + glutathione | - |
Homo sapiens | monomethylarsonous acid + oxidized glutathione | - |
? | |
| monomethylarsonate + glutathione | - |
Oryctolagus cuniculus | monomethylarsonous acid + oxidized glutathione | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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