Literature summary for 1.2.4.2 extracted from

Nemeria, N.S.; Ambrus, A.; Patel, H.; Gerfen, G.; Adam-Vizi, V.; Tretter, L.; Zhou, J.; Wang, J.; Jordan, F.
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate (2014), J. Biol. Chem., 289, 29859-29873.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	2 mM used in assay conditions	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine	Homo sapiens	-	[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
nickel-Sepharose column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine	-	Homo sapiens	[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
2-oxoglutarate dehydrogenase complex E1 component	-	Homo sapiens
E1o	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Homo sapiens

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Release 2023.1 (January 2023)