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Literature summary for 1.2.3.1 extracted from

  • Hutzler, J.M.; Yang, Y.S.; Albaugh, D.; Fullenwider, C.L.; Schmenk, J.; Fisher, M.B.
    Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes (2012), Drug Metab. Dispos., 40, 267-275.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
hydralazine upon coincubation of BIBX1382, carbazeran, and O6-benzylguanine with 50 microM hydralazine, metabolic clearance is substantially attenuated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BIBX1382 + H2O + O2 high hepatic clearance of 17 to 18 ml/(min * kg) Homo sapiens BIBU1476 + ? product identification by high-resolution mass spectrometry ?
carbazeran + H2O + O2 high hepatic clearance of 17 to 18 ml/(min * kg) Homo sapiens carbazeran phthalazinone + ? product identification by high-resolution mass spectrometry ?
additional information hepatic clearance for substrates of aldehyde oxidase i.e. BIBX1382, carbazeran, O6-benzylguanine, zaleplon, and XK-469 is investigated using cryopreserved hepatocytes Homo sapiens ? confirmation of aldehyde oxidase mediated metabolism via incubations in the presence of water containing the 18-O isotope and corresponding isotope patterns in mass spectra ?
O6-benzylguanine + H2O + O2 hepatic clearance of 11.2 to 12.8 ml/(min * kg) Homo sapiens O6-benzyl-8-oxoguanine + ? product identification by high-resolution mass spectrometry ?
XK-469 + H2O + O2 hepatic clearance less than 4.3 ml/(min * kg) Homo sapiens 3-oxo-XK-469 + ? product identification by high-resolution mass spectrometry ?
zaleplon + H2O + O2 hepatic clearance less than 4.3 ml/(min * kg) Homo sapiens 5-oxozaleplon + ? product identification by high-resolution mass spectrometry ?