Activating Compound | Comment | Organism | Structure |
---|---|---|---|
menadione | inhibitory versus substrates vanillin and phenanthridine, activating versus substrate xanthine | Cavia porcellus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-catechin | - |
Cavia porcellus | |
(-)-epicatechin | - |
Cavia porcellus | |
hesperetin | - |
Cavia porcellus | |
menadione | inhibitory versus substrates vanillin and phenanthridine, activating versus substrate xanthine | Cavia porcellus | |
additional information | oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine. A rather plan structure is essential for a potent inhibitory effect and substitution by sugar moieties reduces the inhibitory effects | Cavia porcellus | |
morin | - |
Cavia porcellus | |
myricetin | inhibition of both aldehyde oxidase and xanthine oxidase | Cavia porcellus | |
naringenin | - |
Cavia porcellus | |
quercetin | inhibition of both aldehyde oxidase and xanthine oxidase | Cavia porcellus | |
taxifolin | - |
Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Cavia porcellus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phenanthridine + H2O + O2 | oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine | Cavia porcellus | 6-phenantridone + H2O2 | - |
? | |
vanillin + H2O + O2 | oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine | Cavia porcellus | vanillic acid + H2O2 | - |
? | |
xanthine + H2O + O2 | - |
Cavia porcellus | ? + H2O2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | quercetin | |
0.0004 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | menadione | |
0.0004 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | myricetin | |
0.0004 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | myricetin | |
0.0007 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | quercetin | |
0.0007 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | quercetin | |
0.0019 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | menadione | |
0.0021 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | myricetin | |
0.0025 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | (+)-catechin | |
0.0034 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | naringenin | |
0.0037 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | morin | |
0.0041 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | taxifolin | |
0.0043 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | hesperetin | |
0.0057 | - |
substrate vanillin, pH 7.0, 37°C | Cavia porcellus | (-)-epicatechin | |
0.0061 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | (-)-epicatechin | |
0.0061 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | (+)-catechin | |
0.0069 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | morin | |
0.0088 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | naringenin | |
0.0098 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | hesperetin | |
0.0147 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | taxifolin | |
0.0251 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | naringenin | |
0.0266 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | hesperetin | |
0.0285 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | taxifolin | |
0.0301 | - |
substrate phenanthridine, pH 7.0, 37°C | Cavia porcellus | morin | |
0.0592 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | (-)-epicatechin | |
0.0709 | - |
substrate xanthine, pH 7.0, 37°C | Cavia porcellus | (+)-catechin |