Literature summary for 1.2.3.1 extracted from

Tayama, Y.; Miyake, K.; Sugihara, K.; Kitamura, S.; Kobayashi, M.; Morita, S.; Ohta, S.; Kihira, K.
Developmental changes of aldehyde oxidase activity in young Japanese children (2007), Clin. Pharmacol. Ther., 81, 567-572.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	significant correlations between aldehyde oxidase activity and various growth indices like age, body weight, body surface area, and liver volume. Aldehyde oxidase activity rapidly increases with increase of age up to about 1 year. No differences in sex, but individual variation of developmental changes in aldehyde oxidase activity among monozygotic twins	Homo sapiens

Application

Application	Comment	Organism
medicine	aldehyde oxidase plays an important role in metabolizing many drugs, so aldehyde oxidase activity in individual patients may be a useful parameter for dose adjustment to avoid severe toxicity. Aldehyde oxidase activity is immature in children below 1 year of age, dose adjustment based on individual aldehyde oxidase activity shall be made for such patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Japanese children	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
urine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N1-methylnicotinamide + H2O + O2	-	Homo sapiens	N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2	-	?

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Release 2023.1 (January 2023)