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Literature summary for 1.2.3.1 extracted from
- Guinea pig liver aldehyde oxidase as a sulfoxide reductase: its purification and characterization (1985), Arch. Biochem. Biophys., 242, 213-224.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Amytal | 54% inhibition at 1 mM | Cavia porcellus |  |
| dithiothreitol | 45% and 92% inhibition at 0.1 mM and 1 mM respectively | Cavia porcellus | |
| KCN | complete inhibition at 1 mM when preincubated for 5 min | Cavia porcellus | |
| Triton X-100 | 28% and 63% inhibition at 0.007% with O2 and diphenylsulfoxide as electron acceptor respectively | Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | 8.5 g per mol native enzyme | Cavia porcellus | |
| Mo5+ | 1 g per mol native enzyme | Cavia porcellus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 148000 | - |
alpha2, 2 * 148000, SDS-PAGE | Cavia porcellus |
| 300000 | - |
gel filtration | Cavia porcellus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0078 | - |
sulfoxide reductase activity | Cavia porcellus |
| 0.0094 | - |
- |
Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-hydroxypyrimidine + H2O + O2 | ferricyanide as electron acceptor under aerobic conditions | Cavia porcellus | uracil + H2O2 | - |
? | |
| 2-hydroxypyrimidine + H2O + O2 | diphenylsulfoxide as electron acceptor under anaerobic conditions | Cavia porcellus | uracil + H2O2 | - |
? | |
| acetaldehyde + H2O + O2 | ferricyanide as electron acceptor under aerobic conditions | Cavia porcellus | acetic acid + H2O2 | - |
? | |
| acetaldehyde + H2O + O2 | 2,6-dichlorophenol-indophenol as electron acceptor | Cavia porcellus | acetic acid + H2O2 | - |
? | |
| benzaldehyde + H2O + O2 | diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | benzoic acid + H2O2 | - |
? | |
| butanal + H2O + O2 | ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | butyric acid + H2O2 | - |
? | |
| glyceraldehyde + H2O + O2 | ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | 2,3-dihydroxypropanoic acid + H2O2 | - |
? | |
| glycoaldehyde + H2O + O2 | ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | hydroxyacetic acid + H2O2 | - |
? | |
| heptanal + H2O + O2 | ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | heptanoic acid + H2O2 | - |
? | |
| additional information | also electron acceptors are dibenzyl sulfoxide, phenothiazine sulfoxide, D-biotin methyl ester d-sulfoxide and quinoline N-oxide | Cavia porcellus | ? | - |
? | |
| N1-methylnicotinamide + H2O + O2 | diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide as electron acceptor under aerobic conditions | Cavia porcellus | N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2 | - |
? | |
| propionaldehyde + H2O + O2 | ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions | Cavia porcellus | propionic acid + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alpha2, 2 * 148000, SDS-PAGE | Cavia porcellus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Cavia porcellus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Cavia porcellus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | 2.1 mol per mol native enzyme | Cavia porcellus | |
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