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Literature summary for 1.2.1.3 extracted from

  • Moreb, J.S.; Ucar, D.; Han, S.; Amory, J.K.; Goldstein, A.S.; Ostmark, B.; Chang, L.J.
    The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance (2012), Chem. Biol. Interact., 195, 52-60.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ALDH isoenzymes play a major role in the biology and drug resistance of various malignant cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli K-562 and H-1299 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diethylaminobenzaldehyde 0.025 mM diethylaminobenzaldehyde inhibits about 80% of the enzymatic activity Homo sapiens
Disulfiram 0.025 mM diethylaminobenzaldehyde inhibits about 20-30% of the enzymatic activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P05091
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propionaldehyde + NAD+ + H2O
-
Homo sapiens propionate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
ALDH2 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the proliferation rate and the ability to form colonies is significantly increased by the overexpression of isoform ALDH2 Homo sapiens