Application | Comment | Organism |
---|---|---|
medicine | ALDH isoenzymes play a major role in the biology and drug resistance of various malignant cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli K-562 and H-1299 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethylaminobenzaldehyde | 0.025 mM diethylaminobenzaldehyde inhibits about 80% of the enzymatic activity | Homo sapiens | |
Disulfiram | 0.025 mM diethylaminobenzaldehyde inhibits about 20-30% of the enzymatic activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05091 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propionaldehyde + NAD+ + H2O | - |
Homo sapiens | propionate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH2 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the proliferation rate and the ability to form colonies is significantly increased by the overexpression of isoform ALDH2 | Homo sapiens |