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Literature summary for 1.2.1.3 extracted from

  • Allen, E.M.; Anderson, D.G.; Florang, V.R.; Khanna, M.; Hurley, T.D.; Doorn, J.A.
    Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition (2010), Chem. Res. Toxicol., 23, 1843-1850.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C302S no reactivity is observed for either molinate or molinate sulfone with the C302S mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
molinate irreversible inhibition of ALDH2 Homo sapiens
molinate sulfoxide i.e. S-ethyl-hexahydro-1H-azepine-1-carbothioate sulfoxide, irreversible inhibition of ALDH2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.375
-
recombinant enzyme, using propionaldehyde as the substrate, in 50 mM sodium phosphate buffer, pH 7.4, at 37°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propionaldehyde + NAD+ + H2O
-
Homo sapiens propionate + NADH
-
?

Synonyms

Synonyms Comment Organism
aldehyde dehydrogenase 2
-
Homo sapiens
ALDH2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens