Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.3 extracted from

  • Chen, C.H.; Sun, L.; Mochly-Rosen, D.
    Mitochondrial aldehyde dehydrogenase and cardiac diseases (2010), Cardiovasc. Res., 88, 51-57.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Alda-1 Alda-1 increases the affinity of ALDH2 for NAD+ which results in increased ALDH2 activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Protein Variants

Protein Variants Comment Organism
E487K the mutation results in disruption of the co-enzyme NAD+ binding and reduced catalytic activity of ALDH2 (1-5% of wild type ALDH activity) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-2-nonenal 4-hydroxy-2-nonenal completely inactivates ALDH2 activity in vitro at 100 mM Homo sapiens
nitroglycerin ALDH2 dehydrogenase activity is inhibited by about 50% by large doses of nitroglycerin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetaldehyde + NAD+ + H2O Homo sapiens
-
acetate + NADH + H+
-
?
additional information Homo sapiens ALDH2 is a direct downstream substrate of epsilon protein kinase C ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
myocardium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
?
additional information ALDH2 is a direct downstream substrate of epsilon protein kinase C Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homotetramer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
ALDH2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
malfunction the loss of ALDH2 enzyme activity leads to increased mitochondrial oxidative stress in aortic endothelia by three pro-oxidant stimuli, nitroglycerin, doxorubicin, and acetaldehyde Homo sapiens
physiological function ALDH2 reduces cardiac damage caused by ischaemia insult. ALDH2 protects the heart from aldehyde toxicity and is able to elicit signalling events that can protect against myocardial damages caused by acute ethanol toxicity Homo sapiens