Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Alda-1 | Alda-1 increases the affinity of ALDH2 for NAD+ which results in increased ALDH2 activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E487K | the mutation results in disruption of the co-enzyme NAD+ binding and reduced catalytic activity of ALDH2 (1-5% of wild type ALDH activity) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal completely inactivates ALDH2 activity in vitro at 100 mM | Homo sapiens | |
nitroglycerin | ALDH2 dehydrogenase activity is inhibited by about 50% by large doses of nitroglycerin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + NAD+ + H2O | Homo sapiens | - |
acetate + NADH + H+ | - |
? | |
additional information | Homo sapiens | ALDH2 is a direct downstream substrate of epsilon protein kinase C | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
myocardium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
additional information | ALDH2 is a direct downstream substrate of epsilon protein kinase C | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ALDH2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the loss of ALDH2 enzyme activity leads to increased mitochondrial oxidative stress in aortic endothelia by three pro-oxidant stimuli, nitroglycerin, doxorubicin, and acetaldehyde | Homo sapiens |
physiological function | ALDH2 reduces cardiac damage caused by ischaemia insult. ALDH2 protects the heart from aldehyde toxicity and is able to elicit signalling events that can protect against myocardial damages caused by acute ethanol toxicity | Homo sapiens |