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Literature summary for 1.2.1.3 extracted from

  • Quash, G.; Fournet, G.; Courvoisier, C.; Martinez, R.M.; Chantepie, J.; Paret, M.J.; Pharaboz, J.; Joly-Pharaboz, M.O.; Gore, J.; Andre, J.; Reichert, U.
    Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture (2008), Eur. J. Med. Chem., 43, 906-916.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dimethyl ampal thiolester 78% inhibition of isozyme ALDH1 at 0.0075 mM Homo sapiens
methyl ampal thiolester 32% inhibition of isozyme ALDH1 at 0.0075 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-
endothelial cell
-
Homo sapiens
-
HPENC cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
ALDH1 isozyme Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens