Literature summary for 1.2.1.3 extracted from

Han, I.O.; Joo, C.N.
Purification and characterization of the rat liver mitochondrial aldehyde dehydrogenase (1991), Hanguk Saenghwahakhoe Chi, 24, 353-360.

No PubMed abstract available

Search for more literature for 1.2.1.3

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0033	-	propanal	isoenzyme ALDH-II	Rattus norvegicus
0.005	-	acetaldehyde	isoenzyme ALDH-II	Rattus norvegicus
0.0062	-	Glutaraldehyde	isoenzyme ALDH-II	Rattus norvegicus
0.017	-	3,4-dihydroxyphenyl acetaldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus
0.018	-	p-nitrobenzaldehyde	isoenzyme ALDH-II	Rattus norvegicus
0.023	-	(3,4-dihydroxyphenyl)(hydroxy)acetaldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus
0.026	-	5-hydroxyindol acetaldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus
0.03	-	NAD+	isoenzyme ALDH-II	Rattus norvegicus
0.038	-	NAD+	isoenzyme ALDH-I	Rattus norvegicus
0.05	-	Glutaraldehyde	isoenzyme ALDH-I	Rattus norvegicus
0.056	-	p-nitrobenzaldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus
0.22	-	acetaldehyde	isoenzyme ALDH-I	Rattus norvegicus
0.5	-	propanal	isoenzyme ALDH-I	Rattus norvegicus
0.56	-	Glutaraldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus
2	-	propanal	membrane-bound isoenzyme ALDH	Rattus norvegicus
2	-	p-nitrobenzaldehyde	isoenzyme ALDH-I	Rattus norvegicus
10	-	acetaldehyde	membrane-bound isoenzyme ALDH	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
204000	-	isoenzyme ALDH-II, gel filtration	Rattus norvegicus
234000	-	isoenzyme ALDH-I, gel filtration	Rattus norvegicus
237000	-	membrane-bound isoenzyme ALDH, gel filtration	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	membrane-bound ALDH, ALDH-I: soluble high Km ALDH, and ALDH-II: low Km ALDH	-

Purification (Commentary)

Purification (Comment)	Organism
membrane-bound ALDH, ALDH-I: soluble high Km ALDH, and ALDH-II: low Km ALDH	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
127	-	soluble isoenzyme ALDH-II	Rattus norvegicus
150	-	soluble isoenzyme ALDH-I	Rattus norvegicus
311	-	membrane-bound isoenzyme ALDH	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-dihydroxymandelic aldehyde + NAD+ + H2O	-	Rattus norvegicus	3,4-dihydroxymandelate + NADH	-	?
3,4-dihydroxyphenyl acetaldehyde + NAD+ + H2O	-	Rattus norvegicus	3,4-dihydroxyphenylacetate + NADH	-	?
5-hydroxyindol acetaldehyde + NAD+ + H2O	-	Rattus norvegicus	5-hydroxyindol acetate + NADH + H+	-	?
acetaldehyde + NAD+ + H2O	-	Rattus norvegicus	acetate + NADH + H+	-	?
glutaraldehyde + NAD+ + H2O	-	Rattus norvegicus	glutarate + NADH	-	?
p-nitrobenzaldehyde + NAD+ + H2O	-	Rattus norvegicus	p-nitrobenzoate + NADH	-	?
propanal + NAD+ + H2O	-	Rattus norvegicus	propionate + NADH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Rattus norvegicus

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Release 2023.1 (January 2023)