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Literature summary for 1.2.1.10 extracted from

  • Smith, N.E.; Vrielink, A.; Attwood, P.V.; Corry, B.
    Binding and channeling of alternative substrates in the enzyme DmpFG: a molecular dynamics study (2014), Biophys. J., 106, 1681-1690.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
I159A site-directed mutagenesis, the barrier into the dehydrogenase active site region has been virtually eliminated such that acetaldehyde is transported from one active site to the other in a downhill process Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas sp. DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview ?
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additional information Pseudomonas sp. CF 600 DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview ?
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Organism

Organism UniProt Comment Textmining
Pseudomonas sp. Q52060 dmpF
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Pseudomonas sp. CF 600 Q52060 dmpF
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview Pseudomonas sp. ?
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additional information DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview Pseudomonas sp. CF 600 ?
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?

Subunits

Subunits Comment Organism
More DmpFG is a microbial enzyme comprised of two subunits DmpG and DmpF Pseudomonas sp.

Synonyms

Synonyms Comment Organism
DmpFG
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Pseudomonas sp.

General Information

General Information Comment Organism
metabolism DmpFG catalyzes the final two steps of the meta-cleavage pathway of catechol and its methylated substituents. This pathway breaks down toxic waste products such as naphthalenes, salicylates, and benzoates to harmless metabolites Pseudomonas sp.