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Literature summary for 1.2.1.10 extracted from

  • Manjasetty, B.A.; Powlowski, J.; Vrielink, A.
    Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate (2003), Proc. Natl. Acad. Sci. USA, 100, 6992-6997.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.10

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Pseudomonas sp.

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate
-
 Pseudomonas sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
-
 Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetaldehyde + CoA + NAD+ Pseudomonas sp. involved in degradation of toxic aromatic compounds via the intermediate catechol acetyl-CoA + NADH
-
 r
acetaldehyde + CoA + NAD+ Pseudomonas sp. CF 600 involved in degradation of toxic aromatic compounds via the intermediate catechol acetyl-CoA + NADH
-
 r

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
-
-
Pseudomonas sp. CF 600
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+ part of a bifunctional enzyme complex that also displays 4-hydroxy-2-ketovalerate aldolase activity Pseudomonas sp.
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + CoA + NAD+
-
 Pseudomonas sp. acetyl-CoA + NADH
-
 r
acetaldehyde + CoA + NAD+ involved in degradation of toxic aromatic compounds via the intermediate catechol Pseudomonas sp. acetyl-CoA + NADH
-
 r
acetaldehyde + CoA + NAD+
-
 Pseudomonas sp. CF 600 acetyl-CoA + NADH
-
 r
acetaldehyde + CoA + NAD+ involved in degradation of toxic aromatic compounds via the intermediate catechol Pseudomonas sp. CF 600 acetyl-CoA + NADH
-
 r

Subunits

Subunits Comment Organism
tetramer composed of two dimers, one dimer accounts for 4-hydroxy-2-ketovalerate aldolase, subunit size 37500, and one for acylating acetaldehyde dehydrogenase, subunit size 32500 Pseudomonas sp.

Synonyms

Synonyms Comment Organism
4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase bifunctional enzyme Pseudomonas sp.

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Pseudomonas sp.