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Literature summary for 1.17.1.4 extracted from

  • Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.
    Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens (2009), Comp. Biochem. Physiol. C, 151, 12-17.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Gallus gallus
-
xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O Gallus gallus
-
urate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
domesticus, male chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Gallus gallus
-
kidney
-
Gallus gallus
-
liver
-
Gallus gallus
-
pancreas
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
tissue-dependent enzyme activity, overview Gallus gallus
17.5
-
pancreas enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
17.8
-
pancreas enzyme Gallus gallus
25.2
-
intestine enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
26.6
-
intestine enzyme Gallus gallus
29.5
-
kidney enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
49.9
-
kidney enzyme Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
Gallus gallus xanthine + NADH + H+
-
?
xanthine + NAD+ + H2O
-
Gallus gallus urate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
xanthine oxidoreductase
-
Gallus gallus
XOR
-
Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
41
-
assay at Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Gallus gallus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Gallus gallus