Application | Comment | Organism |
---|---|---|
medicine | cocaine-induced cardiac disfunction is associated with an increase in NADPH oxidase and xanthine oxidoreductase activities by 59% and 29%, respectively, and a decrease in catalase activity. Apocynin or allopurinol treatment prevents the cocaine-induced cardiac alteration by restoration of cardiac output, stroke volume and fractional shortening. This is associated with a reduction of the myocardial production of superoxide anions and an enhancement of catalase activity. Apocynin treatment prevents anthine oxidoreductase up-regulation supporting the hypothesis that NADPH oxidase-derived reactive oxygen species play a role in modulating reactive oxygen species production by xanthine oxidoreductase | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
treated for 7 days with cocaine, or cocaine with a NADPH oxidase inhibitor apocynin, or cocaine with a xanthine oxidoreductase inhibitor allopurinol | - |