Literature summary for 1.17.1.4 extracted from

Omura, K.; Nakazawa, T.; Sato, T.; Iwanaga, T.; Nagata, O.
Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor (2007), Drug Metab. Dispos., 35, 2143-2148.

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Application

Application	Comment	Organism
medicine	the enzyme inhibitor 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile, i.e. FYX-051, is modified in vivo by N1- and N2-glucuronidation, mainly catalyzed by UDP-glucuronosyltransferase UGT1A9	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile	i.e. FYX-051, inhibition of xanthine oxidoreductase. In vivo, the inhibitor is modified by N1- and N2-glucuronidation, mainly catalyzed by UDP-glucuronosyltransferase UGT1A9	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Homo sapiens	-
liver	-	Homo sapiens	-

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Release 2023.1 (January 2023)