Literature summary for 1.17.1.4 extracted from

Okamoto, K.; Matsumoto, K.; Hille, R.; Eger, B.T.; Pai, E.F.; Nishino, T.
The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition (2004), Proc. Natl. Acad. Sci. USA, 101, 7931-7936.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor FYX051, which is slowly hydroxylated by the enzyme	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile	i.e. FYX-051, strong, in absence of xanthine slow hydroxylation of inhibitor	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P80457	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
xanthine + NAD+ + H2O = urate + NADH + H+	catalytically labile Mo-OH oxygen forms a bond with a carbon atom of substrate, the Mo=S group of the oxidized enzyme becomes protonated to afford Mo-SH on reduction of the molybdenum center	Bos taurus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
milk	-	Bos taurus	-

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Release 2023.1 (January 2023)