Literature summary for 1.16.1.1 extracted from

Miller, S.M.; Ballou, D.P.; Massey, V.; Williams, C.H.; Walsh, C.T.
Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction (1986), J. Biol. Chem., 261, 8081-8084.

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Activating Compound

Activating Compound	Comment	Organism	Structure
thiol	exogenous thiols are required for catalytic reduction of Hg(II) to Hg2+, due to prevention or reversal of formation of an abortive complex of Hg(II) with the thiol/thiolate pair of two-electron reduced enzyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	W3110 lacIq containing the plasmid pPSO1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Hg2+ + NADPH	-	Escherichia coli	Hg + NADP+ + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Escherichia coli

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Release 2023.1 (January 2023)