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Literature summary for 1.15.1.1 extracted from

  • Quint, P.; Reutzel, R.; Mikulski, R.; McKenna, R.; Silverman, D.N.
    Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation (2006), Free Radic. Biol. Med., 40, 453-458.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
comparison of native protein and enzyme nitrated at active site residue Y34, no significant change in conformation upon nitration Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
peroxynitrite almost complete inhibition via nitration of active-site residue Y34, no significant change in conformation upon nitration. Inhibition occurs either through a steric effect of 3-nitrotyrosine 34 that impedes substrate binding or through an electrostatic effect of the nitro group Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P04179 MnSOD
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