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Literature summary for 1.14.19.1 extracted from
- Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization (2013), Bioorg. Med. Chem. Lett., 23, 1817-1822.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(4-phenoxyphenyl)-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus |  |
| 2-(4-phenoxyphenyl)-N-(2-phenylethyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| 2-(thiophen-2-yl)-N-(2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1H-benzimidazol-5-yl)acetamide | - |
Rattus norvegicus | |
| 2-[4-(2-chlorophenoxy)phenyl]-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| 2-[4-(2-chlorophenoxy)phenyl]-N-(2-cyclopropylethyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| 2-[4-(2-chlorophenoxy)phenyl]-N-(3-methylbutyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| 2-[4-(2-chlorophenoxy)phenyl]-N-[(5-chlorothiophen-2-yl)methyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| 3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)-N-(1,3-thiazol-2-ylmethyl)benzamide | - |
Rattus norvegicus | |
| ethyl 2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxylate | - |
Rattus norvegicus | |
| N-(1,3-thiazol-2-yl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(1,3-thiazol-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(2-cyclopropylethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(2-cyclopropylethyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(3-methylbutyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(3-phenylpropyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(cyclopropylmethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-(thiophen-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-methyl-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| N-[(5-chlorothiophen-2-yl)methyl]-3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)benzamide | - |
Rattus norvegicus | |
| N-[2-(5-chlorothiophen-2-yl)ethyl]-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | - |
Rattus norvegicus | |
| SAR707 | - |
Rattus norvegicus | |
| [2-(biphenyl-4-yl)-1H-benzimidazol-5-yl](phenyl)methanone | - |
Rattus norvegicus | |
| [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl](phenyl)methanone | - |
Rattus norvegicus | |
| [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanol | - |
Rattus norvegicus | |
| [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanone | - |
Rattus norvegicus | |
| [4-(5-benzoyl-1H-benzimidazol-2-yl)phenyl][2-(trifluoromethyl)phenyl]methanone | - |
Rattus norvegicus | |
| [5-[6-(benzyloxy)pyridazin-3-yl]-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-(trifluoromethyl)phenyl]methanone | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCD1 | - |
Rattus norvegicus |
| stearoyl-CoA desaturase | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000078 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(1,3-thiazol-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000082 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanol | |
| 0.000099 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(thiophen-2-ylmethyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000115 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-chlorophenoxy)phenyl]-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide | |
| 0.000136 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000142 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[(5-chlorothiophen-2-yl)methyl]-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000212 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-chlorophenoxy)phenyl]-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide | |
| 0.00037 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[2-(5-chlorothiophen-2-yl)ethyl]-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | |
| 0.000434 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000539 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(2-cyclopropylethyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.000832 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-chlorophenoxy)phenyl]-N-[(5-chlorothiophen-2-yl)methyl]-1H-benzimidazole-5-carboxamide | |
| 0.000966 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-chlorophenoxy)phenyl]-N-(2-cyclopropylethyl)-1H-benzimidazole-5-carboxamide | |
| 0.0013 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)-N-(1,3-thiazol-2-ylmethyl)benzamide | |
| 0.00221 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-[(5-chlorothiophen-2-yl)methyl]-3-(5-[hydroxy[2-(trifluoromethyl)phenyl]methyl]-1H-benzimidazol-2-yl)benzamide | |
| 0.00272 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-[4-(2-chlorophenoxy)phenyl]-N-(3-methylbutyl)-1H-benzimidazole-5-carboxamide | |
| 0.0032 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-(thiophen-2-yl)-N-(2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1H-benzimidazol-5-yl)acetamide | |
| 0.00386 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(3-methylbutyl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.00452 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(1,3-thiazol-2-yl)-2-[4-[2-(trifluoromethyl)benzoyl]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.00651 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-(4-phenoxyphenyl)-N-(1,3-thiazol-2-ylmethyl)-1H-benzimidazole-5-carboxamide | |
| 0.0133 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl][2-(trifluoromethyl)phenyl]methanone | |
| 0.0158 | - |
pH and temperature not specified in the publication | Rattus norvegicus | [2-[4-(benzyloxy)phenyl]-1H-benzimidazol-5-yl](phenyl)methanone | |
| 0.0166 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(cyclopropylmethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | |
| 0.0216 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(3-methylbutyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | |
| 0.0249 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(2-cyclopropylethyl)-2-(4-phenoxyphenyl)-1H-benzimidazole-5-carboxamide | |
| 0.0272 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-methyl-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.0283 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-(4-phenoxyphenyl)-N-(2-phenylethyl)-1H-benzimidazole-5-carboxamide | |
| 0.0383 | - |
pH and temperature not specified in the publication | Rattus norvegicus | ethyl 2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxylate | |
| 0.1 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(3-phenylpropyl)-2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-1H-benzimidazole-5-carboxamide | |
| 0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Rattus norvegicus | [2-(biphenyl-4-yl)-1H-benzimidazol-5-yl](phenyl)methanone | |
| 0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Rattus norvegicus | [4-(5-benzoyl-1H-benzimidazol-2-yl)phenyl][2-(trifluoromethyl)phenyl]methanone | |
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