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Literature summary for 1.14.19.1 extracted from

  • Gratraud, P.; Huws, E.; Falkard, B.; Adjalley, S.; Fidock, D.A.; Berry, L.; Jacobs, W.R.; Baird, M.S.; Vial, H.; Kremer, L.
    Oleic acid biosynthesis in Plasmodium falciparum: Characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target (2009), PLoS ONE, 4, e6889.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Inhibitors

Inhibitors Comment Organism Structure
methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
-
 Plasmodium falciparum
methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
-
 Plasmodium falciparum
methyl malvalate
-
 Plasmodium falciparum
methyl sterculate inhibits the synthesis of oleic acid both with parasite lysates and infected erythrocytes, most likely by targeting SCD Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0566
-
 stearoyl-CoA in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Plasmodium falciparum 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
114000
-
 calculated from amino acid sequence Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8I0W9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
schizont
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + NADPH + H+ + O2
-
 Plasmodium falciparum oleoyl-CoA + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD
-
 Plasmodium falciparum
stearoyl-CoA desaturase
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Plasmodium falciparum
NADPH SCD is mainly dependent on NADPH, no oleic acid is produced in the absence of NADPH Plasmodium falciparum

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium falciparum calculated from amino acid sequence
-
 9.2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.041
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl 8-methoxy-8-(2-octylcycloprop-1-en-1-yl)octanoate
0.08
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl 9-(2-octylcycloprop-1-en-1-yl)nonanoate
0.087
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl sterculate
0.167
-
 in 0.1 M potassium phosphate buffer pH 7.2, at 37°C Plasmodium falciparum methyl malvalate

Expression

Organism Comment Expression
Plasmodium falciparum there is a 53fold increase of SCD transcript expression level between 18 and 36 h during the late trophozoite stage up