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Literature summary for 1.14.19.1 extracted from

  • Issandou, M.; Bouillot, A.; Brusq, J.M.; Forest, M.C.; Grillot, D.; Guillard, R.; Martin, S.; Michiels, C.; Sulpice, T.; Daugan, A.
    Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models (2009), Eur. J. Pharmacol., 618, 28-36.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CP-24879 9% inhibition at 0.01 mM Homo sapiens
GSK-993 potent and orally available SCD1 inhibitor, almost complete inhibition at 0.01 mM Homo sapiens
GSK-993 potent and orally available SCD1 inhibitor Rattus norvegicus
trans-10,cis-12 conjugated linoleic acid 95% inhibition at 0.1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + NADH + H+ + O2
-
Homo sapiens oleoyl-CoA + NAD+ + H2O
-
?
stearoyl-CoA + NADH + H+ + O2
-
Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
?

Synonyms

Synonyms Comment Organism
SCD1
-
Homo sapiens
SCD1
-
Rattus norvegicus
stearoyl-CoA desaturase 1
-
Homo sapiens
stearoyl-CoA desaturase 1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
in 50 mM Tris-HCl, pH 7.4, at 25°C Homo sapiens GSK-993
0.00018
-
in 50 mM Tris-HCl, pH 7.4, at 25°C Rattus norvegicus GSK-993