Cloned (Comment) | Organism |
---|---|
expressed in HEK-293A cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | potent and orally efficacious SCD-1 inhibitor | Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | potent and orally efficacious SCD-1 inhibitor | Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide | - |
Homo sapiens | |
3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide | - |
Mus musculus | |
4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide | - |
Mus musculus | |
4-[2-(dimethylamino)ethoxy]-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Homo sapiens | |
4-[2-(dimethylamino)ethoxy]-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | - |
Mus musculus | |
N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | - |
Homo sapiens | |
N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | - |
Mus musculus | |
N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide | - |
Homo sapiens | |
N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide | - |
Mus musculus | |
N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | - |
Homo sapiens | |
N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + NADH + H+ + O2 | - |
Homo sapiens | oleoyl-CoA + NAD+ + H2O | - |
? | |
stearoyl-CoA + NADH + O2 | - |
Mus musculus | oleoyl-CoA + NAD+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD-1 | - |
Mus musculus |
SCD-1 | - |
Homo sapiens |
stearoyl-CoA desaturase-1 | - |
Mus musculus |
stearoyl-CoA desaturase-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000004 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.00000004 | - |
in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide | |
0.0000003 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | |
0.0000004 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.0000004 | - |
in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide | |
0.0000006 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | |
0.0000006 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000002 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000002 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000002 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000003 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000003 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000004 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000004 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000006 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000007 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000008 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide | |
0.000008 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.00001 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide | |
0.000011 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000012 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000015 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000016 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000022 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000032 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide | |
0.000044 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | |
0.000049 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide | |
0.000076 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide | |
0.000145 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide | |
0.000276 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide | |
0.00032 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | |
0.000828 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000836 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.000884 | - |
in 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide | |
0.001 | - |
IC50 above 0.001 mM, n 100 mM sodium phosphate, pH 7.4, at 37°C | Homo sapiens | 3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide | |
0.009999 | - |
IC50 above 0.009999 mM | Homo sapiens | 4-[2-(dimethylamino)ethoxy]-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide | |
0.009999 | - |
IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C | Mus musculus | 3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide |