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Literature summary for 1.14.19.1 extracted from

  • Wang, J.; Yu, L.; Wang, H.; Gao, Y.; Schrementi, J.P.; Porter, R.K.; Yurek, D.A.; Kuo, M.; Suen, C.S.; Cao, G.; Bean, J.S.; Kauffman, R.F.; Qian, Y.
    Identification and characterization of hamster stearoyl-CoA desaturase isoforms (2008), Lipids, 43, 197-205.
    View publication on PubMed
Search for more literature for 1.14.19.1

Cloned(Commentary)

Cloned (Comment) Organism
isozyme SCD1, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes Mesocricetus auratus
isozyme SCD2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes Mesocricetus auratus
isozyme SCD3, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mesocricetus auratus 5783
-
membrane
-
 Mesocricetus auratus 16020
-
microsome
-
 Mesocricetus auratus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, recombinant enzyme, SDS-PAGE Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Mesocricetus auratus rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus A7LCI9 gene SCD1; male hamsters, isozyme SCD1
-
Mesocricetus auratus A7LCJ0 gene SCD2; male hamsters, isozyme SCD2
-
Mesocricetus auratus Q64420 gene SCD3 or FAR-17c; male hamsters, isozyme SCD3
-

Purification (Commentary)

Purification (Comment) Organism
recombinant isozyme SCD1 partially from transfected HEL-293 cells by microsome preparation Mesocricetus auratus
recombinant isozyme SCD2 partially from transfected HEL-293 cells by microsome preparation Mesocricetus auratus
recombinant isozyme SCD3 partially from transfected HEL-293 cells by microsome preparation Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression level of isozyme SCD2 Mesocricetus auratus
-
liver
-
 Mesocricetus auratus
-
liver high expression level of isozyme SCD1 Mesocricetus auratus
-
lung
-
 Mesocricetus auratus
-
additional information isozyme tissue expression analysis Mesocricetus auratus
-
additional information isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues Mesocricetus auratus
-
white adipose tissue
-
 Mesocricetus auratus
-
white adipose tissue high expression level of isozyme SCD1 Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
 Mesocricetus auratus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview Mesocricetus auratus oleoyl-CoA + ferricytochrome b5 + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, recombinant enzyme, SDS-PAGE Mesocricetus auratus

Synonyms

Synonyms Comment Organism
SCD
-
 Mesocricetus auratus
stearoyl-CoA desaturase
-
 Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
ferrocytochrome b5 dependent on, the enzyme also requires the presence of NADH-cytochrome b5 reductase Mesocricetus auratus