Literature summary for 1.14.19.1 extracted from

Christianson, J.L.; Nicoloro, S.; Straubhaar, J.; Czech, M.P.
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells (2008), J. Biol. Chem., 283, 2906-2916.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	SCD2 mRNA expression is elevated 44fold in adipose tissue upon feeding mice a high fat diet, whereas SCD1 shows little response	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
SCD1 and SCD2 expression analysis	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	silencing of SCD1 does not downregulate 3T3-L1 cell differentiation or gene expression, inhibition of adipogenesis caused by SCD2 depletion is associated with a decrease in peroxisome proliferator-activated receptor alpha mRNA and protein, whereas in mature adipocytes loss of SCD2 diminishes PPARalpha protein levels, with little change in mRNA levels and protein translation levels	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	Mus musculus	stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-
adipocyte	-	Mus musculus	-
adipose tissue	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	-	Mus musculus	oleoyl-CoA + ferricytochrome b5 + H2O	-	?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview	Mus musculus	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
SCD1	-	Mus musculus
SCD2	-	Mus musculus
stearoyl-CoA desaturase 1	-	Mus musculus
stearoyl-CoA desaturase 2	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ferrocytochrome b5	-	Mus musculus

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Release 2023.1 (January 2023)