Literature summary for 1.14.19.1 extracted from

Hulver, M.W.; Berggren, J.R.; Carper, M.J.; Miyazaki, M.; Ntambi, J.M.; Hoffman, E.P.; Thyfault, J.P.; Stevens, R.; Dohm, G.L.; Houmard, J.A.; Muoio, D.M.
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans (2005), Cell Metab., 2, 251-261.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in primary human skeletal muscle cells from obese and lean donors, SCD1 mRNA levels are increased 2.8fold, protein levels are increased 5.7fold in myotubes from obese compared to lean subjects	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	muscle	Homo sapiens	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37000	-	Western Blot using an antibody against SCD1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	obesity shows a 3fold increase in transcript level of SCD1	Homo sapiens	-
myotube	immunocytochemistry of day 8 myotubes using an anti-SCD1 antibody, SCD1 mRNA levels are increased 2.8fold and protein levels are increased 5.7fold in myotubes from obese compared to lean subjects	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	mean SCD1 enzyme activity is 2.1fold higher in muscle microsomes prepared from obese compred to lean donors, microsomal preparations from rectus abdominus muscle	Homo sapiens

Synonyms

Synonyms	Comment	Organism
SCD1	-	Homo sapiens

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Release 2023.1 (January 2023)