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Literature summary for 1.14.19.1 extracted from
- Terminal enzyme of stearoyl-CoA desaturation from chicken liver (1981), Methods Enzymol., 71, 252-258.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 reductase | flavoprotein | Gallus gallus |
General Stability
| General Stability | Organism |
|---|---|
| 50% loss of activity caused by repeated freezing and thawing | Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3-Butanedione | reversible | Gallus gallus |  |
| azide | - |
Gallus gallus | |
| CN- | - |
Gallus gallus | |
| Cu2+ | and its acid chelates | Gallus gallus | |
| decanoyl-CoA | competitive inhibitor | Gallus gallus | |
| dodecanoyl-CoA | competitive inhibitor | Gallus gallus | |
| p-chloromercuribenzoate | a sulfonate, reversed by beta-mercaptoethanol | Gallus gallus | |
| Tetranitromethane | - |
Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | membrane bound | Gallus gallus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Gallus gallus | |
| Fe2+ | - |
Gallus gallus | |
| Zn2+ | - |
Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33600 | - |
x * 33600, SDS-PAGE | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| stearoyl-CoA + AH2 + O2 | Gallus gallus | - |
oleoyl-CoA + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| several extractions besides ion-exchange and gel filtration | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.11 | - |
- |
Gallus gallus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable at least 6 months | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myristoyl-CoA + AH2 + O2 | 59% activity of the rate with stearoyl-CoA | Gallus gallus | ? | - |
? | |
| palmitoyl-CoA + AH2 + O2 | 62% activity of the rate with stearoyl-CoA | Gallus gallus | palmitoleoyl-CoA + A | - |
? | |
| stearoyl-CoA + AH2 + O2 | - |
Gallus gallus | oleoyl-CoA + A + H2O | - |
? | |
| stearoyl-CoA + NADH + O2 | - |
Gallus gallus | oleoyl-CoA + NAD+ + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 33600, SDS-PAGE | Gallus gallus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELTA9 terminal desaturase | - |
Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 | hemoprotein | Gallus gallus | |
| NADH | - |
Gallus gallus | |
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Release 2023.1 (January 2023)
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