Inhibitors | Comment | Organism | Structure |
---|---|---|---|
flemichin D | competitive inhibition | Agaricus bisporus | |
fleminchalcone A | i.e. 1-(5-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chroman-8-yl)-3-(4-methoxyphenyl)-propan-1-one, competitive inhibition | Agaricus bisporus | |
fleminchalcone B | i.e. 1-(3,5-dihydroxy-2,2-dimethylchroman-6-yl)-3-(4-methoxyphenyl)propan-1-one, competitive inhibition | Agaricus bisporus | |
fleminchalcone C | i.e. 1-(5-hydroxy-8-(2-hydroxypropan-2-yl)-2,2-dimethyl-7,8-dihydro-2H-furo[2,3-h]chromen-6-yl)-3-(4-methoxyphenyl)propan-1-one, competitive inhibition | Agaricus bisporus | |
khonklonginol H | competitive inhibition | Agaricus bisporus | |
kojic acid | - |
Agaricus bisporus | |
lupinifolin | competitive inhibition | Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00101 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone A | |
0.00128 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone C | |
0.00179 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | flemichin D | |
0.00496 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | khonklonginol H | |
0.00522 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone C | |
0.00748 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | flemichin D | |
0.0112 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | lupinifolin | |
0.0123 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | kojic acid | |
0.0184 | - |
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone B | |
0.0195 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone A | |
0.0204 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | khonklonginol H | |
0.0326 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | fleminchalcone B | |
0.0373 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | kojic acid | |
0.0841 | - |
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C | Agaricus bisporus | lupinifolin |