Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-dimethoxycinnamic acid | 2.5% inhibition at 0.33 mM | Agaricus bisporus | |
3,4-dimethoxydihydrocinnamic acid | 20.2% inhibition at 1 mM | Agaricus bisporus | |
4-coumaric acid | 74.4% inhibition at 0.33 mM | Agaricus bisporus | |
4-methoxycinnamic acid | 55.2% inhibition at 1 mM | Agaricus bisporus | |
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one | - |
Agaricus bisporus | |
arbutin | - |
Agaricus bisporus | |
caffeic acid | 6.6% inhibition at 1 mM | Agaricus bisporus | |
Cinnamic acid | 49.3% inhibition at 1 mM | Agaricus bisporus | |
dihydro-4-coumaric acid | 19.6% inhibition at 1 mM | Agaricus bisporus | |
dihydro-4-methoxycinnamic acid | 46.4% inhibition at 1 mM | Agaricus bisporus | |
dihydrocaffeic acid | 2.7% inhibition at 1 mM | Agaricus bisporus | |
dihydrocinnamic acid | 40.5% inhibition at 1 mM | Agaricus bisporus | |
dihydroferulic acid | 17.9% inhibition at 1 mM | Agaricus bisporus | |
dihydroisoferulic acid | 60.6% inhibition at 0.33 mM | Agaricus bisporus | |
dihydrosinapic acid | 22.6% inhibition at 1 mM | Agaricus bisporus | |
ferulic acid | 3.3% inhibition at 0.33 mM | Agaricus bisporus | |
isoferulic acid | 77.8% inhibition at 0.33 mM | Agaricus bisporus | |
Sinapic acid | 1.6% inhibition at 1 mM | Agaricus bisporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | Agaricus bisporus | - |
L-DOPA + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | - |
Agaricus bisporus | L-DOPA + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0516 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one | |
0.1149 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | isoferulic acid | |
0.1156 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | 4-coumaric acid | |
0.1957 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydroisoferulic acid | |
0.2105 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | arbutin | |
0.8617 | - |
in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | 4-methoxycinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | caffeic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | ferulic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | Cinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | Sinapic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | 3,4-dimethoxycinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydrocaffeic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydrocinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydro-4-coumaric acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydro-4-methoxycinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydroferulic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | 3,4-dimethoxydihydrocinnamic acid | |
1 | - |
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C | Agaricus bisporus | dihydrosinapic acid |