Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2':4',2''-ter-1,3,4-oxadiazole-5,5',5''(4H,4''H)-trithione | - |
Agaricus bisporus | |
2,2':4',2''-ter-1,3,4-thiadiazole-5,5',5''(4H,4''H)-trithione | - |
Agaricus bisporus | |
4,4'-diamino-3-(4-hydroxyphenyl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione | - |
Agaricus bisporus | |
4,4'-diamino-3-(pyridin-4-yl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione | - |
Agaricus bisporus | |
4-(benzyloxy)-N'-(hydrazinylcarbonyl)benzohydrazide | - |
Agaricus bisporus | |
5'-(3-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(4-[[tert-butyl(dimethyl)silyl]oxy]phenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(diphenylmethyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(diphenylmethyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(naphthalen-1-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(pyridin-4-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-(pyridin-4-yl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-benzyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-cyclohexyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-phenyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-phenyl-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-[3-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
5'-[4-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | - |
Agaricus bisporus | |
kojic acid | - |
Agaricus bisporus | |
N'-(hydrazinylcarbonyl)-4-hydroxybenzohydrazide | - |
Agaricus bisporus | |
N'-(hydrazinylcarbonyl)naphthalene-2-carbohydrazide | - |
Agaricus bisporus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | the enzyme contains copper | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa + O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
monophenol, o-diphenol:oxygen oxidoreductase | - |
Agaricus bisporus |
tyrosinase | - |
Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0223 | - |
kojic acid | in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00019 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.00049 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.00053 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(4-[[tert-butyl(dimethyl)silyl]oxy]phenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.00101 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 4,4'-diamino-3-(pyridin-4-yl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione | |
0.00131 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-phenyl-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.00135 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-[4-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.00177 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0019 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0024 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 4,4'-diamino-3-(4-hydroxyphenyl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione | |
0.00247 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(pyridin-4-yl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.0029 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 2,2':4',2''-ter-1,3,4-thiadiazole-5,5',5''(4H,4''H)-trithione | |
0.00364 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-[3-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.00367 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-benzyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.00442 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.00494 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-cyclohexyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0052 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(diphenylmethyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione | |
0.00647 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-phenyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.00676 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(diphenylmethyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0142 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(pyridin-4-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0185 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(3-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.0336 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 5'-(naphthalen-1-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione | |
0.049 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 4-(benzyloxy)-N'-(hydrazinylcarbonyl)benzohydrazide | |
0.0694 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | 2,2':4',2''-ter-1,3,4-oxadiazole-5,5',5''(4H,4''H)-trithione | |
0.1772 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | N'-(hydrazinylcarbonyl)-4-hydroxybenzohydrazide | |
0.996 | - |
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C | Agaricus bisporus | N'-(hydrazinylcarbonyl)naphthalene-2-carbohydrazide |