Literature summary for 1.14.18.1 extracted from

Munoz-Munoz, J.L.; Garcia-Molina, F.; Garcia-Ruiz, P.A.; Varon, R.; Tudela, J.; Garcia-Canovas, F.; Rodriguez-Lopez, J.N.
Stereospecific inactivation of tyrosinase by L- and D-ascorbic acid (2009), Biochim. Biophys. Acta, 1794, 244-253.

Search for more literature for 1.14.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
D-ascorbic acid	met-tyrosinase is stable in anaerobic conditions but, in the presence of D-ascorbic acid undergoes an inactivation	Agaricus bisporus
L-ascorbic acid	met-tyrosinase is stable in anaerobic conditions but, in the presence of L-ascorbic acid undergoes an inactivation	Agaricus bisporus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.79	-	L-ascorbic acid	-	Agaricus bisporus
4.28	-	D-ascorbic acid	-	Agaricus bisporus
393	-	O2	using D-ascorbic acid as cosubstrate	Agaricus bisporus
421	-	O2	using L-ascorbic acid as cosubstrate	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-dopaxanthin + dehydroascorbic acid + O2	-	Agaricus bisporus	(R)-dopaxanthin quinone + L-ascorbic acid + H2O	-	?
D-ascorbic acid + O2	-	Agaricus bisporus	?	-	r

Synonyms

Synonyms	Comment	Organism
deoxy-tyrosinase	-	Agaricus bisporus
met-tyrosinase	-	Agaricus bisporus
polyphenol oxidase	-	Agaricus bisporus
tyrosinase	-	Agaricus bisporus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.92	-	D-ascorbic acid	-	Agaricus bisporus
0.97	-	L-ascorbic acid	-	Agaricus bisporus

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
210	-	D-ascorbic acid	-	Agaricus bisporus
340	-	L-ascorbic acid	-	Agaricus bisporus

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Release 2023.1 (January 2023)