Literature summary for 1.14.18.1 extracted from

Chien, C.C.; Tsai, M.L.; Chen, C.C.; Chang, S.J.; Tseng, C.H.
Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms (2008), Mycopathologia, 166, 117-120.

Search for more literature for 1.14.18.1

Application

Application	Comment	Organism
drug development	the finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their healing properties in various Chinese traditional herbal on skin care products. Tyrosinase inhibitors are effective components of skin-lightening compounds and cosmetics	Agaricus bisporus

Inhibitors

Inhibitors	Comment	Organism	Structure
Antrodia camphorata extract	basidiomycete, only other effect on tyrosinase activity is prepared from Antrodia camphorata using 75% ethanol extraction	Agaricus bisporus
Ganoderma lucidum extract	basidiomycete, also known as Lingzhi in the herbal medicine community, exhibits significant inhibition of tyrosinase activity. No difference in inhibitory effects on tyrosinase activity is observed by Ganoderma lucidum extracts obtained by the three different extraction methods (75%, 50% ethanol, and distilled water extraction)	Agaricus bisporus
additional information	extracts of Antrodia camphorata prepared by 50% extraction and distilled water, and all extracts prepared from Agaricus brasiliensis and Cordyceps militaris show less than 25% inhibition in the reaction mixtures contained 1 mg/ml extracts. No significant inhibitory effect on tyrosinase activity is observed when 0.1 mg/ml extracts are used in the reaction mixture	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Agaricus bisporus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	350 Units/ml tyrosinase activity in extracts from Ganoderma lucidum, in extracts from Antrodia camphorata IC50 is about 1 mg/ml	Agaricus bisporus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + O2 + AH2	-	Agaricus bisporus	L-dopa + H2O + A	-	?

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	Ganoderma lucidum exhibits significant inhibition of tyrosinase activity, IC50 value 0.32 mg/ml	Agaricus bisporus	additional information

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Release 2023.1 (January 2023)