Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane | tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. Synthetic and plant derived versions of the enzyme inhibit mushroom tyrosinase with similar potencies | Agaricus bisporus | |
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane | tyrosinase inhibitor with strong depigmenting effects, found in the medicinal plant Dianella ensifolia. 22times more potent than kojic acid | Mus musculus | |
2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol | plant-derived diarylpropane tyrosinase inhibitor | Agaricus bisporus | |
4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol | plant-derived diarylpropane tyrosinase inhibitor | Agaricus bisporus | |
kojic acid | commonly used tyrosinase inhibitor | Agaricus bisporus | |
kojic acid | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-F1 cell | mouse melanoma cell | Mus musculus | - |
commercial preparation | - |
Agaricus bisporus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dopa + 1/2 O2 | - |
Mus musculus | L-dopaquinone + H2O | - |
? | |
L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dopa oxidase | DOPA oxidase activity of murine tyrosinase | Mus musculus |
tyrosinase | - |
Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane | inhibition is competitive and reversible, about 15times more potent than kojic acid | Agaricus bisporus | |
0.0043 | - |
kojic acid | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00024 | - |
- |
Agaricus bisporus | 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane | |
0.001 | - |
- |
Agaricus bisporus | 2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol | |
0.012 | - |
- |
Mus musculus | 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane | |
0.024 | - |
- |
Agaricus bisporus | 4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol | |
0.273 | - |
- |
Mus musculus | kojic acid |