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Literature summary for 1.14.18.1 extracted from

  • Xiao, L.; Matsubayashi, K.; Miwa, N.
    Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues (2007), Arch. Dermatol. Res., 299, 245-257.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information UVA induced oxidative stress is considered to promote melanogenesis and serious skin damage. UVA-induced reactive oxygen species (ROS), ROS causes tyrosinase gene transcription Homo sapiens

Application

Application Comment Organism
pharmacology results indicate that the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) could be expected for its wide-ranged application as a whitening cosmetic material Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
arbutin as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens
L-ascorbic acid as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens
polyvinylpyrrolidone (PVP)-wrapped fullerene derivative inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene, named Radical Sponge. As compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HMV-II cell human melanoma cell Homo sapiens
-
NHEM cell human normal epidermis melanocytes Homo sapiens
-
skin human fresh skin tissues from volunteers Homo sapiens
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Synonyms

Synonyms Comment Organism
tyrosinase
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Homo sapiens