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Literature summary for 1.14.17.1 extracted from

  • Fan, Y.; Huang, J.; Kieran, N.; Zhu, M.Y.
    Effects of transcription factors Phox2 on expression of norepinephrine transporter and dopamine beta-hydroxylase in SK-N-BE(2)C cells (2009), J. Neurochem., 110, 1502-1513.
    View publication on PubMed
Search for more literature for 1.14.17.1

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
SK-N-BE(2)C cell neuroblastoma cell line Homo sapiens
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Synonyms

Synonyms Comment Organism
DBH
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 Homo sapiens
dopamine beta-hydroxylase
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduces mRNA and protein levels of DBH after shutdown of endogenous Phox2, which is accompanied by a decreased [(3)H]norepinephrine uptake. Reduced DBH expression caused by the shRNA specific to Phox2a can be reversed by transfection with Phox2b cDNA and vice versa. Cotransfection with both shRNAs specific to Phox2a and Phox2b genes does not further reduce mRNA and protein levels of DBH down
Homo sapiens transfection of 0.1 to 5 microg of cDNAs of Phox2a or Phox2b significantly increases mRNA and protein levels of DBH (up to 47%) in a concentration-dependent manner. Simultanoeus transfection with both Phox2a and Phox2b does not further increase mRNA and protein levels of DBH up

General Information

General Information Comment Organism
physiological function determinant role of Phox2a and Phox2b on the expression and function of DBH in vitro Homo sapiens