Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate the enzyme in NCI-H295 cells, leptin negatively controls ACTH/cholera toxin-induced CYP11A1 promoter activity to inhibit P450scc expression, mechanism, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenal ferredoxin + O2 | Homo sapiens | first and rate-limiting enzyme in adrenal steroidogenesis | pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin | - |
? | |
additional information | Homo sapiens | leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene CYP11A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NCI-H295 cell | adrenocortical cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin | - |
? | |
cholesterol + reduced adrenal ferredoxin + O2 | first and rate-limiting enzyme in adrenal steroidogenesis | Homo sapiens | pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin | - |
? | |
additional information | leptin interferes with adrenocorticotropin/cAMP signaling, possibly through a janus kinase 2-phosphatidylinositol 3-kinase/akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line, mechanism, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol side-chain cleavage cytochrome P450 enzyme | - |
Homo sapiens |
P450 cholesterol side-chain cleavage enzyme | - |
Homo sapiens |
P450scc | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |