Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.6 extracted from

  • Tsujita, M.; Ichikawa, Y.
    Substrate-binding region of cytochrome P-450scc (P-450 XIA1). Identification and primary structure of the cholesterol binding region in cytochrome P-450scc (1993), Biochim. Biophys. Acta, 1161, 124-130.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K267Q participation in electrostatic interaction of P-450scc with adrenodoxin Bos taurus
K403Q participation in electrostatic interaction of P-450scc with adrenodoxin Bos taurus
K405Q participation in electrostatic interaction of P-450scc with adrenodoxin Bos taurus
R426Q participation in electrostatic interaction of P-450scc with adrenodoxin Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
methoxychlor pesticide of DDT, suicide inhibitor, competitive to cholesterol, substantial irreversible loss of activity, 5% inhibition within 5 min at 0.2 mM, decrease is suppressed by the presence of cholesterol Bos taurus
additional information inactivation different in absence and presence of cholesterol, protective effect of cholesterol as well as 20alpha-hydroxycholesterol and deoxycorticosterone against inactivation by methoxychlor Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.164
-
cholesterol
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Bos taurus 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + 6 reduced adrenodoxin + 3 O2 Bos taurus
-
pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O precursor of all steroid hormones ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + 6 reduced adrenodoxin + 3 O2
-
Bos taurus pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O precursor of all steroid hormones ?
cholesterol + reduced adrenodoxin + O2
-
Bos taurus pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?
additional information 21 amino-acid residues from Pro-8 to Arg-28 in the amino-terminus are located in or near the cholesterol-binding site, this site is in a quite different region from the adreno-ferredoxin binding site Pro374 to Iso-389 Bos taurus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Bos taurus
heme hemeprotein Bos taurus
heme content of 18.9 nmol/mg protein Bos taurus
NADPH NADPH-linked adrenodoxin reductase Bos taurus