Protein Variants | Comment | Organism |
---|---|---|
additional information | congenital adrenal hyperplasia due to steroid 11beta-hydroxylase deficiency is a genetic disorder of steroidogenesis, transmitted as an autosomal recessive trait. It is associated with low renin hypertension, hypokalemia, hyperandrogenemia and genital ambiguity in affected females, phenotype including female pseudohermaphroditism and partially with hypertension, diagnostic steroid pattern of 11beta-hydroxylase deficiency, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
11-deoxycorticosterone + adrenal ferredoxin + ? | - |
? | |
cortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | in the adrenal zona fasciculata | 11-deoxycortisol + adrenal ferredoxin + ? | - |
? | |
additional information | Homo sapiens | congenital adrenal hyperplasia due to steroid 11beta-hydroxylase deficiency is a genetic disorder of steroidogenesis, transmitted as an autosomal recessive trait. It is associated with low renin hypertension, hypokalemia, hyperandrogenemia and genital ambiguity in affected females, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | zona fasciculata in the adrenal cortex | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | 11-deoxycorticosterone + adrenal ferredoxin + ? | - |
? | |
cortisol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | 11-deoxycortisol + adrenal ferredoxin + ? | - |
? | |
cortisol + reduced adrenal ferredoxin + O2 | in the adrenal zona fasciculata | Homo sapiens | 11-deoxycortisol + adrenal ferredoxin + ? | - |
? | |
additional information | congenital adrenal hyperplasia due to steroid 11beta-hydroxylase deficiency is a genetic disorder of steroidogenesis, transmitted as an autosomal recessive trait. It is associated with low renin hypertension, hypokalemia, hyperandrogenemia and genital ambiguity in affected females, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid 11beta-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |