Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sertraline + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
sertraline + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
erythromycin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
fluoxetine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
S-mephenytoin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
sertraline + [reduced NADPH-hemoprotein reductase] + O2 | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | Homo sapiens | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
sertraline + [reduced NADPH-hemoprotein reductase] + O2 | i.e. (1S,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a one-step oxidative N-demethylation | Rattus norvegicus | demethylsertraline + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-demethylase | - |
Homo sapiens |
N-demethylase | - |
Rattus norvegicus |
O-demethylase | - |
Homo sapiens |
O-demethylase | - |
Rattus norvegicus |
sertraline N-demethylase | - |
Homo sapiens |
sertraline N-demethylase | - |
Rattus norvegicus |