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Literature summary for 1.14.14.1 extracted from

  • Hardstone, M.C.; Leichter, C.A.; Scott, J.G.
    Multiplicative interaction between the two major mechanisms of permethrin resistance, kdr and cytochrome P450-monooxygenase detoxification, in mosquitoes (2009), J. Evol. Biol., 22, 416-423.
    View publication on PubMed

Application

Application Comment Organism
medicine the two major mechanisms that confer resistance to permethrin in Culex mosquitoes are target site insensitivity (i.e. kdr) and enhanced detoxification by cytochrome P450 monooxygenases Culex quinquefasciatus

Organism

Organism UniProt Comment Textmining
Culex quinquefasciatus
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Synonyms

Synonyms Comment Organism
cytochrome P450-monooxygenase
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Culex quinquefasciatus

General Information

General Information Comment Organism
physiological function for all genotype combinations tested, the mosquitoe exhibits multiplicative interactions between kdr and P450 detoxification, whether the resistance alleles are homozygous or heterozygous Culex quinquefasciatus