Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
mitochondrial inner membrane | CYP24A1 and CYP27A1 | Homo sapiens | 5743 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | an electron transferred to CYP(Fe3+), interacting with the proper substrate, reduces Fe3+ in the heme system to Fe2+, allowing a consequent interaction of the CYP(Fe2+)-substrate complex with O2. The second transferred electron allows for transformation of the O2-CYP(Fe2+)-substrate complex into a form with an anion potentialized reactive oxygen species -O2-CYP(Fe2+)-substrate, permitting destabilization of the bond between the atoms of the oxygen molecule to form a bond of one of the oxygen atoms with the substrate. The second oxygen atom is reduced to H2O by reductive equivalent transport systems (cytochrome P450 reductase, cytochrome b5 reductase/cytochrome b5, adrenodoxin reductase/adrenodoxin) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CYP monooxygenase | - |
Homo sapiens |
CYP24A1 | - |
Homo sapiens |
CYP27A1 | - |
Homo sapiens |
CYP5A1 | - |
Homo sapiens |
CYP8A1 | - |
Homo sapiens |
cytochrome P450 monooxygenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Homo sapiens | |
FAD | - |
Homo sapiens | |
FMN | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |