KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0229 | - |
5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one | isozyme FMO1, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C | Homo sapiens | |
0.05903 | - |
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one | isozyme FMO1, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C | Homo sapiens | |
0.4314 | - |
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one | isozyme FMO5, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01740 | isozyme FMO1 | - |
Homo sapiens | Q9HA79 | isozyme FMO5 | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 | i.e. C-1305 | Rattus norvegicus | 5-[[3-(dimethylnitroryl)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O | - |
? | |
5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 | i.e. C-1305 | Homo sapiens | 5-[[3-(dimethylnitroryl)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O | - |
? | |
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 | i.e. C-1299 | Rattus norvegicus | 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O | - |
? | |
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 | i.e. C-1299 | Homo sapiens | 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O | - |
? | |
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 | i.e. C-1305 | Homo sapiens | 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O | - |
? | |
additional information | isozyme FMO5 does not metabolize 5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one (C-1305) | Rattus norvegicus | ? | - |
? | |
additional information | isozyme FMO5 does not metabolize C-1305 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin-containing monooxygenase | - |
Rattus norvegicus |
flavin-containing monooxygenase | - |
Homo sapiens |
FMO1 | isozyme | Rattus norvegicus |
FMO1 | isozyme | Homo sapiens |
FMO5 | isozyme | Rattus norvegicus |
FMO5 | isozyme | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.4 | 8.4 | the activity is approximately twice as high at pH 8.4 as at pH 7.4 | Rattus norvegicus |
7.4 | 8.4 | the activity is approximately twice as high at pH 8.4 as at pH 7.4 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
FAD | - |
Homo sapiens | |
NADPH | required for activity | Rattus norvegicus | |
NADPH | required for activity | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the flavin monooxygenase FMO1 contributes to metabolism of anti-tumor triazoloacridinone C-1305 (5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one) in liver microsomes | Rattus norvegicus |
metabolism | the flavin monooxygenase FMO1 contributes to metabolism of anti-tumor triazoloacridinone, C-1305 (5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one), in liver microsomes and Hep-G2 cells | Homo sapiens |